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This is a reflection of the characteristics that bison share with cattle. Though the American bison is not only a separate species, but also is usually regarded bucfalo being in buffalk separate genus from domestic cattle Bos taurusthey clearly Lamb escort a lot of genetic compatibility and American bison can interbreed Asian buffalo dating cattle, although only the female offspring are fertile in the first generation. Many ranchers have deliberately crossbred their cattle with bison, and some natural hybridization could be expected in areas where cattle and bison occur in the same range.

Since cattle and bison eat similar food and tolerate similar conditions, they have often been in the same range together in the past, and opportunity for crossbreeding may sometimes have been common. In recent decades, tests were developed to determine the source of mitochondrial DNA in cattle and bison, and most private "buffalo" herds were actually crossbred with cattle, and even most state and federal buffalo herds had some cattle DNA. With the advent of nuclear microsatellite DNA testing, the number of herds known to contain cattle genes has increased.

Though aboutbison exist on private ranches and in public herds, perhaps only 15, to 25, of these bison are pure and not actually bison-cattle hybrids. One possible explanation for this might be the small amount of domestic cattle genes that are now in most bison populations, though this is not the only possible explanation for bison success. A wood bison around Coal River in Canada In the study, cattle genes were also found in small amounts throughout most national, state and private herds. However, the extension of this herd into the Book Cliffs of central Utah involved mixing the founders with additional bison from another source, so it is not known if the Book Cliffs extension of the herd is also free of cattle hybridization.

A separate study by Wilson and Strobeck, published in Genome, was done to define the relationships between different herds of bison in the United States and Canada, and to determine whether the bison at Wood Buffalo National Park in Canada and the Yellowstone Park bison herd were possibly separate subspecies. The Wood Buffalo Park bison were determined to actually be crossbreeds between plains and wood bison, but their predominant genetic makeup was that of the expected "wood buffalo".